Is routine genetic testing warranted in head and neck paragangliomas?
نویسندگان
چکیده
منابع مشابه
Head and neck paragangliomas: clinical and molecular genetic classification
Head and neck paragangliomas are tumors arising from specialized neural crest cells. Prominent locations are the carotid body along with the vagal, jugular, and tympanic glomus. Head and neck paragangliomas are slowly growing tumors, with some carotid body tumors being reported to exist for many years as a painless lateral mass on the neck. Symptoms depend on the specific locations. In contrast...
متن کاملGenetics of hereditary head and neck paragangliomas.
BACKGROUND The purpose of this study was to give an overview on hereditary syndromes associated with head and neck paragangliomas (HNPGs). METHODS Our methods were the review and discussion of the pertinent literature. RESULTS About one third of all patients with HNPGs are carriers of germline mutations. Hereditary HNPGs have been described in association with mutations of 10 different gene...
متن کاملTreatment of Head and Neck Paragangliomas.
BACKGROUND Commonly occurring in the head and neck, paragangliomas are typically benign, highly vascular neoplasms embryologically originating from the extra-adrenal paraganglia of the neural crest. Frequently, these tumors are associated with the vagus or tympanic plexus nerve or the carotid artery, or jugular bulb. Their clinical presentation can vary across a wide spectrum of signs and sympt...
متن کاملHead and neck paragangliomas: an overview.
Paragangliomas of the head and neck are unique tumors. Their pathology, tissue of origin, location, genetics, potential for bio-chemical activity, multicentricity, and growth pattern are unusual compared with more common head and neck tumors. Because these tumors are widespread and can appear in the ear, neck, larynx, nose, orbit, and chest, they cross subspecialties of otolaryngology.
متن کاملMalignant head/neck paragangliomas. Comparative study.
BACKGROUND The objective of this study was to report 11 cases of malignant head and neck paraganglioma and to compare their epidemiological, clinical, and genetic characteristics, their natural history and their treatment with those of a series of 131 benign paragangliomas. PATIENTS AND METHODS Retrospective analysis of 142 patients with head and neck paraganglioma managed between 2001 and 20...
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ژورنال
عنوان ژورنال: The Laryngoscope
سال: 2018
ISSN: 0023-852X
DOI: 10.1002/lary.27656